A novel method of deriving the effect compartment equilibrium rate constant for propofol
نویسندگان
چکیده
منابع مشابه
Titration of the plasma effect site equilibrium rate constant of propofol; a link method of 'Concentration-Probability-Time'
BACKGROUND The plasma effect-site equilibrium rate constant (k(e0)) of propofol has been reported in various pharmacodynamic studies; however, it is not desirable to apply k(e0) for the link with pharmacokinetic models that were separately investigated. Thus, we titrated k(e0) for the pharmacokinetic model, which is known as the multiple covariates adjusted model of propofol. METHODS Ninety f...
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15 صفحه اولEstimating the plasma effect-site equilibrium rate constant (Ke₀) of propofol by fitting time of loss and recovery of consciousness.
The present paper proposes a new approach for fitting the plasma effect-site equilibrium rate constant (Ke0) of propofol to satisfy the condition that the effect-site concentration (Ce) is equal at the time of loss of consciousness (LOC) and recovery of consciousness (ROC). Forty patients receiving intravenous anesthesia were divided into 4 groups and injected propofol 1.4, 1.6, 1.8, or 2 mg/kg...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2003
ISSN: 0007-0912
DOI: 10.1093/bja/aeg228